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Normal processing of proinsulin, the insulin precursor molecule, is initiated in β-cells by cleavage at the B-chain/C-peptide junction (Arg 32 ↓Glu 33), preferentially by the prohormone convertase enzyme PC3 (also known as PC1 or PC1/3), resulting in the formation of des 31,32 proinsulin after removal of the two COOH-terminal arginine residues (Arg 31-Arg 32) from the B-chain by. " These chemicals are changed by the body to other "muscle-building" hormones such as testosterone. 4 Andro, a prohormone that can potentially be a. This prohormone will increase muscle strength and size as well as support weight loss. Enhanced 3-AD has quickly become our number one selling prohormone and for good reason, it is the best prohormone for. On its own, 4-Androstenediol does not have a prominent androgen receptor binding affinity, but as a prohormone it converts to testosterone via the enzyme 3-beta hydroxysteroid dehydrogenase (3bHSD). 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